Protein Details: Potassium voltage-gated channel subfamily H member 4

Protein ID

ICDB_Pro_1621

Protein Name

Potassium voltage-gated channel subfamily H member 4

Gene Name

Kcnh4; Elk1; Elk3

Organism

Rattus norvegicus (Rat)

Length

1017 amino acids

AlphaFoldDB

AF-Q9R1T9-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current; but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNELGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNNHENSLGRRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVFEPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDNTVLAILGKGDLIGADIPELGQEPGAGAGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGMEPGAGSKPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGSSPSLHGPPRGSAAWKPPQLLTPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPLSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPPSHPPDSTWLPDLPCPHQRPPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSELRSSMVPPFPSEPDPLGPSPVPEASPLTPSLLKHSFQSGSDTFH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

557..672

Disease

Location

Highly expressed in adult testis; and in adult and embryonic brain. In adult brain found in piriform cortex; olfactory tubercle; cerebral cortex; hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus. Detected at intermediate levels in lung; spinal cord; and pituitary.

DOI ID

10.1111/j.1469-7793.1998.647ba.x; 10.1074/jbc.274.35.25018; 10.1523/jneurosci.21-13-04609.2001

RefSeq

NP_446082.1